Members of the Frizzled family of sevenpass transmembrane proteins serve as receptors for Wnt signalling proteins Wnt proteins have important roles in the differentiation and patterning of diverse tissues during animal development, and inappropriate activation of Wnt signalling pathways is a key feature of many cancers An extracellular cysteinerich domainLes protéines transmembranaires Frizzled (Fz) sont une famille de récepteurs couplés aux protéines G (RCPG) qui tiennent notamment un rôle dans la voie de signalisation WntL'activation du récepteur conduit à l'activation de la protéine Dishevelled dans le cytosol Fonctions Les protéines Frizzled jouent aussi un rôle essentiel dans le contrôle de la polarité cellulaire, leWNT/Frizzled signalling receptor–ligand selectivity with focus on FZDG protein signalling and its physiological relevance IUPHAR Review 3 J P Dijksterhuis, Section of Receptor Biology and Signaling, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden These authors contributed equally to this work Search for more papers by this author J
Human Cellexp Trade Frizzled 4 Fzd4 Protein Human Recombinant Protein 268
